1995, B.S. Chemistry, University of Wisconsin-Eau Claire
1999, M.S. Chemistry, Arizona State University
2000, Ph.D. Chemistry, The University of Michigan
2000-2002, NIH Postdoctoral Fellow, California Institute of Technology
2003, ACS PMSE Division Arthur K. Doolittle Award
2005, NSF CAREER Award
2005, Sigma Xi Outstanding Young Investigator Award
2005, Beckman Young Investigator Award
2007, Alfred P. Sloan Fellow
2008, Camille Dreyfus Teacher-Scholar Award

Materials chemistry is making a tremendous impact on modern medicine and biological research. Synthetic polymers that are compatible with biological systems are playing an important role in the diagnosis and treatment of many diseases. Consequently, understanding how synthetic biomaterials interact with and affect living systems is one of the most fundamental and important problems in biomedical research. To this end, we are interested in the development of novel carbohydrate-based polymers and dendrimers for the cellular delivery of DNA therapeutics, glycopolymer contrast agents for magnetic resonance imaging, and luminescent macrocyclic compounds for anion sensing. Studies in these areas are also centered on understanding the cellular mechanisms of biomaterial internalization and intracellular trafficking, their cellular function, and toxicity by designing and synthesizing novel systems to aid our understanding of these phenomena. Our research is highly interdisciplinary and students in the Reineke lab routinely receive training in several areas of chemistry, biology, and medicine.

1. Srinivasachari, K. M. Fichter, T. M. Reineke, "Polycationic á-Cyclodextrin "Click Clusters": Monodisperse and Versatile Scaffolds for Nucleic Acid Delivery", J. Am. Chem. Soc. 2008, 130, 4618-4627.
2. Lucas, M. Benjamin, T. M. Reineke, "Comparison of a Tartaric Acid Derived Polymeric MRI Contrast Agent to a Small Molecule Model Chelate" Bioconjugate Chem. 2008, 19, 24-27.
3. S. Srinivasachari, Y. Liu, G. Zhang, L. Prevette, T. M. Reineke, "Trehalose Click Polymers Inhibit Nanoparticle Aggregation and Promote pDNA Delivery in Serum" J. Am. Chem. Soc. 2006 128, 8176-8184.
4. Liu, T. M. Reineke, "Hydroxyl Stereochemistry and Amine Number within Poly(glycoamidoamine)s Affect Intracellular DNA Delivery" J. Am. Chem. Soc. 2005, 127, 3004-3015.
5. Liu, L. Wenning, M. Lynch, and T. M. Reineke, "New Poly(D-glucaramidoamine)s Induce DNA Nanoparticle Formation and Efficient Gene Delivery into Mammalian Cells" J. Am. Chem. Soc. 2004 126, 7422-7423.